WASHINGTON (AP) — She tried gums, patches and various electronic cigarettes to quit smoking. What finally
worked for Chantel Williams was a small, reusable e-cigarette called Juul that packs a big nicotine
punch.
"I look better. I feel better and I don’t smell. It’s fantastic," said Williams of Portland,
Oregon, who smoked for decades.
That nicotine hit and its easy-to-inhale vapor is one reason why Juul is so popular — and so feared.
"That’s the trouble with Juul: It’s probably the worst for kids but it might be the best for adult
smokers," said Dr. Nancy Rigotti, a tobacco treatment specialist at Harvard Medical School.
The brainchild of two Stanford University design students, Juul launched in 2015 and quickly leapfrogged
over its competitors to become the top-selling e-cigarette in the U.S. Today, the privately held company
controls nearly three-quarters of the $3.7 billion-dollar retail market for e-cigarettes, spawning
dozens of copycat brands along the way.
With Juul’s rise came an explosion of underage vaping, alarming public health officials and lawmakers.
Last year, 1 in 5 U.S. high school students reported vaping in the previous month, according to a
government survey.
Juul and other pod-based vaping devices can be used discreetly, without the smoke, odor or throat
irritation that deterred some teenagers from smoking. E-cigarettes typically heat a solution containing
nicotine into a vapor, and health experts say the addictive chemical is harmful to developing brains.
Recent research published shows some teenagers aren’t even aware they are inhaling nicotine when using
Juul and similar e-cigarettes.
Proposals to keep e-cigarettes away from teenagers include banning flavored solutions, restricting where
they can be sold and raising the purchase age to 21, which some states have done.
Less attention has been paid to Juul’s quick, powerful buzz.
Abbey Solomon first began seeing Juul around the house when her son Jack was in 8th grade.
Like many parents, she didn’t initially recognize the small, rechargeable device, which resembles a flash
drive, as an e-cigarette. But as parents and teachers began sounding the alarm, she started confiscating
Juul and its color-coded flavor pods from her son and his friends.
Last year, Jack, 16, became an unlikely spokesman for the anti-vaping movement, appearing in a viral
video , "Juulers against Juul" to push for tougher restrictions to protect kids.
In the video, he says teenagers will often leave school to get their Juul fix. "It shouldn’t
happen," he said. "But kids are very addicted to these e-cigarettes and need this stuff to be
satisfied."
Jack himself hasn’t been able to quit, his mother says. When she tried to make him stop, "he was
moody, he was complaining, he wasn’t sleeping," says Solomon, of Scarsdale, New York. "He was
miserable because he was going through nicotine withdrawal. He was addicted."
The U.S. Food and Drug Administration has the power to cap nicotine levels in e-cigarettes, but hasn’t
proposed any such standard. For cigarettes, there’s no limit on nicotine, although the FDA has taken
preliminary steps toward reducing levels to help smokers quit. Limiting nicotine in e-cigarettes could
have unintended consequences, including making the products less satisfying for smokers trying to
switch.
Juul declined interviews for this story, but said in a statement that its product is formulated to
"mimic the experience of a cigarette." Its goal is to offer smokers an alternative to
tobacco-burning cigarettes, the company said. Under pressure from regulators, Juul voluntarily shut down
its Facebook and Instagram accounts and pulled several flavors out of stores last November.
Company critics say Juul’s nicotine level may be excessive and should be getting far more scrutiny.
"I think there’s a real question of how addictive these products need to be," said Robin Koval,
CEO of the Truth Initiative, a nonprofit anti-smoking education group.
Juul sells two formulas for most of its flavor pods. One contains 59 milligrams of nicotine per
milliliter of liquid, or roughly three times what can be sold to consumers in Europe, where Juul sells a
20-milligram version of its pods. Juul’s lower-nicotine U.S. version contains 35 milligrams of nicotine
per milliliter, which still exceeds the European limit.
Britain and other nations have had success promoting e-cigarettes as a lower-risk alternative to smokers,
without seeing a surge in underage vaping. But they also have tighter regulations, including strict
limits on advertising.
Juul, like all e-cigarettes in the U.S., has not been approved to help smokers quit. The FDA isn’t
expected to begin reviewing the contents and health effects of e-cigarettes for at least two more years.

While calling underage vaping a "mounting epidemic of youth addiction," recently departed FDA
Commissioner Scott Gottlieb stressed the importance of keeping e-cigarettes available for adult smokers
trying to quit. The FDA and most experts agree that e-cigarettes are probably less harmful than
traditional cigarettes because they don’t produce all of the cancer-causing byproducts of burning
tobacco.
Meanwhile, the vaping industry appears to be following Juul’s lead.
Stanford researchers have identified 39 U.S. devices mimicking Juul’s pod-based design and 71 brands
selling similar high-nicotine solutions.
Juul has published little peer-reviewed research, and only in the last year have independent researchers
begun studying its formula. The company says each of its full-strength pods delivers about as much
nicotine as a pack of cigarettes. But experts note that usage varies widely; some people may vape one
pod a day, others one pod a week.
Most researchers have focused on a more objective measure: the potency of Juul’s nicotine formula, or
e-liquid.
Researchers at Portland State University analyzed the concentration of Juul’s full-strength pod against
nine other nicotine formulas on the market in 2017. Juul’s nicotine level dwarfed its competitors, in
some cases by twentyfold.
Regular cigarettes and older e-cigarettes mainly contain nicotine in its freebase form, which becomes
increasingly harsh on the throat at higher levels. Juul’s innovation was to convert the nicotine to its
salt form by combining it with an acid. The result is a mild vapor that allows even a novice to inhale
large doses of nicotine.
David Peyton, a chemistry professor at Portland State who co-authored the paper, says Juul’s popularity
is due to a combination of its formulation, flavors and marketing efforts.
"It’s very powerful and very attractive," Peyton said.
Adult smokers want something that "will deliver this hit and relieve their nicotine craving as fast
as possible," said Dr. Maciej Goniewicz, a toxicologist at Roswell Park Comprehensive Cancer Center
in Buffalo, New York.
That’s what attracted Chantel Williams to Juul. The 46-year-old social media manager said she began
smoking in grade school. She tried to quit beginning in 2005, using nicotine gum, patches and eventually
e-cigarettes. Refillable vaping devices were "too much work," she said. And other brands
didn’t have the immediacy of a cigarette like Juul.
"You just grab it and you’re taken care of it," she said.
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Follow Matthew Perrone on Twitter: @AP_FDAwriter
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The Associated Press Health and Science Department receives support from the Howard Hughes Medical
Institute’s Department of Science Education. The AP is solely responsible for all content.